Endocrine Abstracts

Introduction: It is accepted that hyperprolactinaemia associated with microprolactinoma may prove self-limiting in 25–30% women, and there is some suggestion from series of mixed gender that the same may be true in men.Methods: We have therefore reviewed the outcome in all men with microprolactinomas managed at the Department of Diabetes and Endocrinology, City Hospital, Nottingham, between 1994 and 2002. All had sustained and previously untreated h...

In 2008, we presented data showing that combining sonography and scintigraphy investigations resulted in the correct identification of a parathyroid adenoma in 97% (28/29) patients undergoing parathyroid surgery for primary hyperparathyroidism (PHPT). Further to this audit we compared the treatment of PHPT against the standards set by NIH in 2008. All patients who had Setamibi +/ ultrasound scan over 18 month (July 2006 until December 2007) for biochemically confirmed PHPT wer...

Introduction: Women with a high breast density have an increased risk of breast cancer, which prevalence increases after menopause in obese subjects. Breast density can be calculated on mammograms as the proportion of dense tissue (percent mammographic density-PMD). Several factors may influence the PMD, including age, menopausal status, body mass index (BMI), and bone mineral density (BMD) taken as an index of overall estrogen exposure. However, conflicting data have been rep...

Aim: Shortage of tetracosactide in the UK has put pressure on clinicians to reduce the number of SST’s ordered. Our aim was to establish if a lower baseline cortisol level from the currently accepted cut-off could predict a positive SST outcome. This would aid our Endocrine Department in rationalising use of tetracosactide.Methods: A retrospective observational study of indications and results of SST’s performed in non-critically ill general me...

We measured chromogranin A (CgA) and chromogranin B (CgB) in 36 patients, recently confirmed to have a midgut carcinoid tumour (MGC), prior to the commencement of octreotide treatment. Blood samples were taken before and after a bolus injection of 50 μg octreotide. There were 21 males, 15 females, age range 28–76 median 61 years.Basal CgA, expressed as times the upper limit of normal (ULN) ranged from 333.3 to 0.5 ULN. Basal CgB ranged from 33....

Abstract: Generously supported by IPSEN)-->Pituitary adenomas (PA) may occur in association with malignancies. Although an increased risk of cancer has been reported in acromegalics, this has been poorly studied in patients with other phenotypes. We wished to evaluate the prevalence of recognized malignancies in PA.Material and Methods: A series of 422 consecutive PA patients followed at the Neuromed Institute ...

Introduction: Cinacalcet acts at the calcium-sensing receptors on parathyroid cells to increase the sensitivity to circulating calcium concentrations. Studies have shown that this treatment is an effective means of managing hypercalcaemia in primary hyperparathyroidism.Aims: The aim of this study was to determine the outcomes of patients who had received cinacalcet for at least 3 months for primary hyperparathyroidism.Methods: We i...

Ollier disease (OD) is a rare disease, with multiple enchondromas localized in the metaphysis of long bones, hands and feet, developing in the first decade of life, with potential malignant transformation into chondrosarcomas. OD is usually sporadic and probably caused by post-zygotic genetic alterations leading to mosaicism. A PTH/PTHrP receptor type 1 (PTHR1) gene mutation is present in some cases.Case report: A 21-years old male patient was referred t...

Aims: Primary hyperparathyroidism is a common endocrine disorder. A preoperative approach that combines ultra-sonography and scintigraphy has been shown to predict the presence of adenomas more accurately than either technique alone. We aimed to investigate our local success rates using dual localisation for parathyroid adenomas.Methods: Endocrine patients who had a parathyroidectomy between July 2006 and January 2008 were identified. Hospital notes were...

The RCP clinical guideline on Radioiodine in the management of benign thyroid disease was published in 2007. An audit was undertaken in patients receiving this treatment between April 2006 and April 2007. The audit was performed to assess compliance with the guidelines and provide patients receiving radioiodine data regarding the efficacy of the treatment and its complications.Sixty-two patients received radioiodine and 59 patients entered into the audit...